-synuclein, and that is a major part of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) tension, recommend that dysfunction with the intracellular proteinase methods, which include ubiquitin-proteasome method or lysosomal system, which gets rid of unneeded tox
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